Introduction: Angiolytic lasers have provided increasing utility in vocal fold conditions for over 20 years. With evolution of technology, such lasers now include diode and solid state with varying wavelengths of 445nm and 532nm. Both blue light and green light lasers demonstrate effective management options on the vocal folds despite subtle differences. Is one a better choice than the other? Methodology: A retrospective chart review analyzed treatment outcomes of consecutive patients with similar conditions treated by a single surgeon with either the KTP 532nm laser or the 445nm Blue laser. Comparisons were made between the treatments and outcomes for each laser. Results: For 44 patients were identified with half each undergoing blue light or green light-assisted treatment for a range of vocal fold conditions: dysplasia, T1-2 glottic cancer, ectasias and varices, stenosis and papilloma. Similar numbers in each group were used. Operative time, ease of laser use, resolution of disease, number of operations, recurrence rate and patient satisfaction were compared. Treatment outcomes were not statistically different between the laser groups but some subtle differences were noted. The lasers themselves will be compared and contrasted. Conclusion: This study indicates that the newer 445nm blue light laser has similar efficacy for conditions treated previously with 532nm KTP laser. There are theoretical advantages of the blue light laser along with some minor technical advantages for ease of use.